Blood stream infection (BSI) and acute GVHD after hematopoietic SCT (HSCT) are associated

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Bone marrow T-cell infiltration during acute GVHD is associated with delayed B-cell recovery and function after HSCT.

B-cell immune dysfunction contributes to the risk of severe infections after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Delayed B-cell regeneration is found in patients with systemic graft-versus-host disease (GVHD) and is often accompanied by bone marrow (BM) suppression. Little is known about human BM GVHD. We analyzed the reconstitution kinetics of B-cell subsets in adul...

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Evaluation of Cyclosporine Pharmacokinetic, Monitoring, and Dosing Parameters for GVHD Prophylaxis in Hematopoietic Stem Cell Transplant (HSCT) Recipients

Allogeneic hematopoietic stem cell transplantation (AHSCT) is a major method of treatmentfor different hematologic and congenital disease. Graft versus host disease (GvHD) is a lifethreateningadverse effect of AHSCT. Cyclosporine is the most important and common agentfor GvHD prophylaxis. Because of variable and unpredictable pharmacokinetics of cyclosporinethat produces...

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Evaluation of Cyclosporine Pharmacokinetic, Monitoring, and Dosing Parameters for GVHD Prophylaxis in Hematopoietic Stem Cell Transplant (HSCT) Recipients

Allogeneic hematopoietic stem cell transplantation (AHSCT) is a major method of treatmentfor different hematologic and congenital disease. Graft versus host disease (GvHD) is a lifethreateningadverse effect of AHSCT. Cyclosporine is the most important and common agentfor GvHD prophylaxis. Because of variable and unpredictable pharmacokinetics of cyclosporinethat produces...

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Thyroid dysfunction after hematopoietic stem cell transplantation in children: older age and acute GVHD might be risk factors of thyroid dysfunction during 3 months after HSCT

We evaluated short term changes in thyroid function in patients who underwent hematopoietic stem cell transplantation (HSCT) during childhood. And we attempted to find clinical and treatment risk factors for thyroid dysfunction during 3 months after HSCT We studied 170 patients (102 boys and 68 girls) who underwent HSCT at the Catholic HSCT center from January, 2004 to December, 2009. Patients ...

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ژورنال

عنوان ژورنال: Bone Marrow Transplantation

سال: 2010

ISSN: 0268-3369,1476-5365

DOI: 10.1038/bmt.2010.112